1354198-41-6
1354198-41-6 structure
- Name: GS 462808
- Chemical Name: GS 462808
- CAS Number: 1354198-41-6
- Molecular Formula: C17H12F3N5O3
- Molecular Weight: 391.31
- Create Date: 2020-01-11 16:54:51
- Modify Date: 2024-01-21 20:12:18
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GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM; has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967; shows improved anti-ischemic potency relative to ranolazine.
| Name | GS 462808 |
|---|
| Description | GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM; has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967; shows improved anti-ischemic potency relative to ranolazine. |
|---|---|
| References | References 1. Koltun DO, et al. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11. View Related Products by Target Sodium Channel |
| Molecular Formula | C17H12F3N5O3 |
|---|---|
| Molecular Weight | 391.31 |