GS 462808
Modify Date: 2025-09-17 01:18:22
GS 462808 structure
|
Common Name | GS 462808 | ||
|---|---|---|---|---|
| CAS Number | 1354198-41-6 | Molecular Weight | 391.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H12F3N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GS 462808GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM; has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967; shows improved anti-ischemic potency relative to ranolazine. |
| Name | GS 462808 |
|---|
| Description | GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM; has lower brain penetration and serendipitously lower activity at the brain isoforms, and improved CNS window (>20 rat and dog) relative to GS-458967; shows improved anti-ischemic potency relative to ranolazine. |
|---|---|
| References | References 1. Koltun DO, et al. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11. View Related Products by Target Sodium Channel |
| Molecular Formula | C17H12F3N5O3 |
|---|---|
| Molecular Weight | 391.31 |
| InChIKey | CIUYUJJQZDDGTM-UHFFFAOYSA-N |
| SMILES | Cc1noc(Cn2nc3ccc(-c4ccc(OC(F)(F)F)cc4)cn3c2=O)n1 |