1380107-92-5
1380107-92-5 structure
- Name: AI-2
- Chemical Name: AI-2
- CAS Number: 1380107-92-5
- Molecular Formula: C18H15ClN2O3
- Molecular Weight: 342.779
- Create Date: 2020-01-11 19:08:39
- Modify Date: 2024-01-05 16:59:48
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Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.
| Name | AI-2 |
|---|
| Description | Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. |
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| References | References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2 |
| Molecular Formula | C18H15ClN2O3 |
|---|---|
| Molecular Weight | 342.779 |