AI-2 structure
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Common Name | AI-2 | ||
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CAS Number | 1380107-92-5 | Molecular Weight | 342.779 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H15ClN2O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of AI-2Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. |
Name | AI-2 |
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Description | Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. |
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References | References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2 |
Molecular Formula | C18H15ClN2O3 |
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Molecular Weight | 342.779 |