AI-2

Modify Date: 2024-01-05 16:59:48

AI-2 Structure
AI-2 structure
Common Name AI-2
CAS Number 1380107-92-5 Molecular Weight 342.779
Density N/A Boiling Point N/A
Molecular Formula C18H15ClN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AI-2


Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.

 Names

Name AI-2

 AI-2 Biological Activity

Description Nrf2 acticatior AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1; exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1; an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.
References References 1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47. View Related Products by Target Keap1-Nrf2

 Chemical & Physical Properties

Molecular Formula C18H15ClN2O3
Molecular Weight 342.779
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