1610676-27-1
1610676-27-1 structure
- Name: CFI-401980
- Chemical Name: CFI-401980
- CAS Number: 1610676-27-1
- Molecular Formula: C28H30N6O3
- Molecular Weight: 498.587
- Create Date: 2020-01-19 22:44:57
- Modify Date: 2023-01-14 18:44:16
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CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM; shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%).
| Name | CFI-401980 |
|---|
| Description | CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM; shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%). |
|---|---|
| References | References 1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK) |
| Molecular Formula | C28H30N6O3 |
|---|---|
| Molecular Weight | 498.587 |