CFI-401980
Modify Date: 2025-08-05 21:00:52
CFI-401980 structure
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Common Name | CFI-401980 | ||
|---|---|---|---|---|
| CAS Number | 1610676-27-1 | Molecular Weight | 498.587 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H30N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CFI-401980CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM; shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%). |
| Name | CFI-401980 |
|---|
| Description | CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM; shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%). |
|---|---|
| References | References 1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK) |
| Molecular Formula | C28H30N6O3 |
|---|---|
| Molecular Weight | 498.587 |
| InChIKey | SPYVZMIWNDEJND-UHFFFAOYSA-N |
| SMILES | Cc1cc(-c2cnn3c(NCC4CCOCC4)nc(Oc4ccccc4)nc23)ccc1C(=O)NC1CC1 |