1817791-73-3
1817791-73-3 structure
- Name: NTRC 00660
- Chemical Name: NTRC 00660
- CAS Number: 1817791-73-3
- Molecular Formula: C33H39N7O2
- Molecular Weight: 565.722
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 18:32:40
- Modify Date: 2024-01-19 10:39:38
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A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel.
| Name | NTRC 00660 |
|---|
| Description | A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel. |
|---|---|
| References | References 1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92. 2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325. 3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK) |
| Molecular Formula | C33H39N7O2 |
|---|---|
| Molecular Weight | 565.722 |