NTRC 00660
Modify Date: 2024-01-19 10:39:38
NTRC 00660 structure
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Common Name | NTRC 00660 | ||
|---|---|---|---|---|
| CAS Number | 1817791-73-3 | Molecular Weight | 565.722 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H39N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NTRC 00660A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel. |
| Name | NTRC 00660 |
|---|
| Description | A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel. |
|---|---|
| References | References 1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92. 2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325. 3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK) |
| Molecular Formula | C33H39N7O2 |
|---|---|
| Molecular Weight | 565.722 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: NTRC 0066-0
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: NTRC 00660
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: NTRC 00660
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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