NTRC 00660
Modify Date: 2024-01-19 10:39:38
NTRC 00660 structure
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Common Name | NTRC 00660 | ||
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| CAS Number | 1817791-73-3 | Molecular Weight | 565.722 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H39N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NTRC 00660A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel. |
| Name | NTRC 00660 |
|---|
| Description | A highly potent, selective inhibitor of checkpoint kinase TTK/Mps1 with IC50 of 0.6 nM; displays >200-fold selectivity over 276 kinases, including Aurora C, PLK1, PLK4; shows very potent anti-proliferative activity on a broad panel of human cancer cell lines (IC50=18- 897 nM); increases the survival in a murine breast cancer model that mimics human TNBC and delays tumor relapse, combined with docetaxel. |
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| References | References 1. Maia AR, et al. Ann Oncol. 2015 Oct;26(10):2180-92. 2. Libouban MAA, et al. Oncotarget. 2017 Jun 13;8(24):38309-38325. 3. Zaman GJR, et al. Mol Cancer Ther. 2017 Jul 27. pii: molcanther.0342.2017. View Related Products by Target Monopolar Spindle 1 (Mps1/TTK) |
| Molecular Formula | C33H39N7O2 |
|---|---|
| Molecular Weight | 565.722 |