188645-44-5
188645-44-5 structure
- Name: LE-540
- Chemical Name: LE-540
- CAS Number: 188645-44-5
- Molecular Formula: C33H32N2O2
- Molecular Weight: 488.631
- Create Date: 2020-01-11 19:15:50
- Modify Date: 2024-02-02 21:37:14
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A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.
| Name | LE-540 |
|---|
| Description | A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα. |
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| References | References 1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6. 2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6. 3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34. View Related Products by Target RAR/RXR |
| Molecular Formula | C33H32N2O2 |
|---|---|
| Molecular Weight | 488.631 |