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  • DC Chemicals Limited
  • China
  • Product Name: LE-540
  • Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

188645-44-5

188645-44-5 structure
188645-44-5 structure
  • Name: LE-540
  • Chemical Name: LE-540
  • CAS Number: 188645-44-5
  • Molecular Formula: C33H32N2O2
  • Molecular Weight: 488.631
  • Create Date: 2020-01-11 19:15:50
  • Modify Date: 2024-02-02 21:37:14
  • A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.

Name LE-540
Description A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.
References References 1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6. 2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6. 3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34. View Related Products by Target RAR/RXR
Molecular Formula C33H32N2O2
Molecular Weight 488.631