1939104-08-1
1939104-08-1 structure
- Name: JH-IX-179
- Chemical Name: JH-IX-179
- CAS Number: 1939104-08-1
- Molecular Formula: C26H24N6O
- Molecular Weight: 436.519
- Create Date: 2020-01-12 13:38:50
- Modify Date: 2024-02-25 19:29:26
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JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively; exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively; JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases; inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells.
| Name | JH-IX-179 |
|---|
| Description | JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively; exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively; JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases; inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells. |
|---|---|
| References | References 1. Hatcher JM, et al. ACS Med Chem Lett. 2016 Mar 8;7(5):476-81. View Related Products by Target FLT3 |
| Molecular Formula | C26H24N6O |
|---|---|
| Molecular Weight | 436.519 |