JH-IX-179
Modify Date: 2024-02-25 19:29:26
JH-IX-179 structure
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Common Name | JH-IX-179 | ||
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| CAS Number | 1939104-08-1 | Molecular Weight | 436.519 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H24N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JH-IX-179JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively; exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively; JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases; inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells. |
| Name | JH-IX-179 |
|---|
| Description | JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively; exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively; JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases; inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells. |
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| References | References 1. Hatcher JM, et al. ACS Med Chem Lett. 2016 Mar 8;7(5):476-81. View Related Products by Target FLT3 |
| Molecular Formula | C26H24N6O |
|---|---|
| Molecular Weight | 436.519 |