2011708-45-3
2011708-45-3 structure
- Name: HER2-IN-3
- Chemical Name: HER2-IN-3
- CAS Number: 2011708-45-3
- Molecular Formula: C20H16N6O2
- Molecular Weight: 372.388
- Create Date: 2020-01-11 20:02:51
- Modify Date: 2024-04-05 19:36:14
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HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2; shows superior activity to lapatinib in the 2YF/3wt + NRG cells and specificity for this cell line; remains sensitivity to HER2 mutations L755S (2YF-L755S/3wt), Y772_A775 dup (2YF-YVMA/3wt), and G776del_insVC (2YF-VC/3wt) cells.
| Name | HER2-IN-3 |
|---|
| Description | HER2-IN-3 is a type I HER2 inhibitor that has a similar profile to HER2-IN-2; shows superior activity to lapatinib in the 2YF/3wt + NRG cells and specificity for this cell line; remains sensitivity to HER2 mutations L755S (2YF-L755S/3wt), Y772_A775 dup (2YF-YVMA/3wt), and G776del_insVC (2YF-VC/3wt) cells. |
|---|---|
| References | References 1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930. View Related Products by Target EGFR |
| Molecular Formula | C20H16N6O2 |
|---|---|
| Molecular Weight | 372.388 |