2014348-91-3
2014348-91-3 structure
- Name: KRM-II-81
- Chemical Name: KRM-II-81
- CAS Number: 2014348-91-3
- Molecular Formula: C21H13N5O
- Molecular Weight: 351.369
- Create Date: 2020-01-14 14:26:29
- Modify Date: 2024-03-25 18:29:49
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KRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors; shows α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits.
| Name | KRM-II-81 |
|---|
| Description | KRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors; shows α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits. |
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| References | References 1. Poe MM, et al. J Med Chem. 2016 Dec 8;59(23):10800-10806. 2. Lewter LA, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1305-1312. View Related Products by Target GABA Receptor |
| Molecular Formula | C21H13N5O |
|---|---|
| Molecular Weight | 351.369 |