79220-94-3

79220-94-3 structure

Name: KRM-III
Chemical Name: 3,5-diphenyl-1H-imidazole-2-thione
CAS Number: 79220-94-3
Molecular Formula: C₁₅H₁₂N₂S
Molecular Weight: 252.33400
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-03-17 01:38:52
Modify Date: 2024-01-15 12:59:13
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].

Name	3,5-diphenyl-1H-imidazole-2-thione
Synonyms	1,4-diphenyl-1H-imidazole-2-thiol KRM-III 1,4-phenyl-1H-imidazole-2-thiol

Description	KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport