KRM-II-81
Modify Date: 2024-03-25 18:29:49
KRM-II-81 structure
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Common Name | KRM-II-81 | ||
|---|---|---|---|---|
| CAS Number | 2014348-91-3 | Molecular Weight | 351.369 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H13N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRM-II-81KRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors; shows α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits. |
| Name | KRM-II-81 |
|---|
| Description | KRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors; shows α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits. |
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| References | References 1. Poe MM, et al. J Med Chem. 2016 Dec 8;59(23):10800-10806. 2. Lewter LA, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1305-1312. View Related Products by Target GABA Receptor |
| Molecular Formula | C21H13N5O |
|---|---|
| Molecular Weight | 351.369 |