2088001-23-2
2088001-23-2 structure
- Name: hTG2 inhibitor VA4
- Chemical Name: hTG2 inhibitor VA4
- CAS Number: 2088001-23-2
- Molecular Formula: C33H41N5O6S
- Molecular Weight: 635.78
- Create Date: 2020-01-20 18:29:56
- Modify Date: 2024-01-19 19:26:25
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hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.
| Name | hTG2 inhibitor VA4 |
|---|
| Description | hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM. |
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| References | References 1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927. 2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11. View Related Products by Target Other Targets |
| Molecular Formula | C33H41N5O6S |
|---|---|
| Molecular Weight | 635.78 |