hTG2 inhibitor VA4
Modify Date: 2024-01-19 19:26:25
hTG2 inhibitor VA4 structure
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Common Name | hTG2 inhibitor VA4 | ||
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| CAS Number | 2088001-23-2 | Molecular Weight | 635.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H41N5O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of hTG2 inhibitor VA4hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM. |
| Name | hTG2 inhibitor VA4 |
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| Description | hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM. |
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| References | References 1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927. 2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11. View Related Products by Target Other Targets |
| Molecular Formula | C33H41N5O6S |
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| Molecular Weight | 635.78 |