hTG2 inhibitor VA4

Modify Date: 2024-01-19 19:26:25

hTG2 inhibitor VA4 Structure
hTG2 inhibitor VA4 structure
Common Name hTG2 inhibitor VA4
CAS Number 2088001-23-2 Molecular Weight 635.78
Density N/A Boiling Point N/A
Molecular Formula C33H41N5O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hTG2 inhibitor VA4


hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.

 Names

Name hTG2 inhibitor VA4

 hTG2 inhibitor VA4 Biological Activity

Description hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.
References References 1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927. 2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11. View Related Products by Target Other Targets

 Chemical & Physical Properties

Molecular Formula C33H41N5O6S
Molecular Weight 635.78
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