2173582-08-4
2173582-08-4 structure
- Name: M-525
- Chemical Name: M-525
- CAS Number: 2173582-08-4
- Molecular Formula: C39H51FN6O5S
- Molecular Weight: 734.932
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-20 12:17:55
- Modify Date: 2024-01-04 11:08:11
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M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM.
| Name | M-525 |
|---|
| Description | M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM. |
|---|---|
| References | References 1. Xu S, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C39H51FN6O5S |
|---|---|
| Molecular Weight | 734.932 |