219963-52-7
219963-52-7 structure
- Name: SB-357134
- Chemical Name: SB-357134
- CAS Number: 219963-52-7
- Molecular Formula: C17H18Br2FN3O3S
- Molecular Weight: 523.22
- Create Date: 2020-01-11 21:05:46
- Modify Date: 2024-04-04 02:00:48
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A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice.
| Name | SB-357134 |
|---|
| Description | A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice. |
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| References | References 1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8. 2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54. 3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306. 4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9. View Related Products by Target 5-HT Receptor |
| Molecular Formula | C17H18Br2FN3O3S |
|---|---|
| Molecular Weight | 523.22 |