SB-357134
Modify Date: 2025-10-24 18:26:36
SB-357134 structure
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Common Name | SB-357134 | ||
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| CAS Number | 219963-52-7 | Molecular Weight | 523.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H18Br2FN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SB-357134A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice. |
| Name | SB-357134 |
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| Description | A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice. |
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| References | References 1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8. 2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54. 3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306. 4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9. View Related Products by Target 5-HT Receptor |
| Molecular Formula | C17H18Br2FN3O3S |
|---|---|
| Molecular Weight | 523.22 |
| InChIKey | BLWHAZZXRHTFJE-UHFFFAOYSA-N |
| SMILES | COc1ccc(S(=O)(=O)Nc2cc(Br)cc(F)c2Br)cc1N1CCNCC1 |