309254-79-3
309254-79-3 structure
- Name: Ro 64-6198 hydrochloride
- Chemical Name: Ro 64-6198 hydrochloride
- CAS Number: 309254-79-3
- Molecular Formula: C26H32ClN3O
- Molecular Weight: 438.012
- Create Date: 2020-01-20 07:30:55
- Modify Date: 2024-01-17 11:08:43
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A nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued
| Name | Ro 64-6198 hydrochloride |
|---|
| Description | A nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued |
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| References | References 1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64. 2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23. 3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. View Related Products by Target Opioid Receptor Anxiety |
| Molecular Formula | C26H32ClN3O |
|---|---|
| Molecular Weight | 438.012 |