246852-46-0

246852-46-0 structure

Name: Ro 64-5229
Chemical Name: Ro 64-5229
CAS Number: 246852-46-0
Molecular Formula: C₁₇H₁₉Cl₂N₃O
Molecular Weight: 352.26
Create Date: 2016-09-27 21:05:47
Modify Date: 2024-01-27 18:45:22
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1[1].

Name	Ro 64-5229

Description	Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGlu2[1].
In Vitro	RO 64-5229 (50 µM) 降低神经连接蛋白 1 的突触前抑制作用[1]。 RO 64-5229 (0.1, 0.3, 1 µM; 20 min) 在 HEK-mGluR2 细胞中抑制 neuroligin 1 ectodomain (Ecto-NL1; mGluR2 激活剂) 对 Forskolin 的抑制活性 (Ecto-NL1 降低了 Forskolin 诱导的 cAMP 形成)[1]。 Immunofluorescence[1] Cell Line: HEK-mGluR2 cells Concentration: 0.1, 0.3, 1 µM Incubation Time: 20 min Result: Inhibited activity of Ecto-NL1( mGluR2 activator).
References	[1]. Gjørlund MD, et al. Soluble Ectodomain of Neuroligin 1 Decreases Synaptic Activity by Activating Metabotropic Glutamate Receptor 2. Front Mol Neurosci. 2017 May 3;10:116.