400863-77-6
400863-77-6 structure
- Name: ST-148
- Chemical Name: ST-148
- CAS Number: 400863-77-6
- Molecular Formula: C21H19N5OS2
- Molecular Weight: 421.537
- Create Date: 2020-01-12 08:23:49
- Modify Date: 2024-01-19 18:22:06
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ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice.
| Name | ST-148 |
|---|
| Description | ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice. |
|---|---|
| References | References 1. Byrd CM, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):15-25. 2. Scaturro P, et al. J Virol. 2014 Oct;88(19):11540-55. View Related Products by Target Filovirus |
| Molecular Formula | C21H19N5OS2 |
|---|---|
| Molecular Weight | 421.537 |