627042-19-7
627042-19-7 structure
- Name: Rac1-IN-1
- Chemical Name: Rac1-IN-1
- CAS Number: 627042-19-7
- Molecular Formula: C19H14N2O5
- Molecular Weight: 350.33
- Create Date: 2020-01-12 19:13:29
- Modify Date: 2023-01-21 22:56:25
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A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 8.3±1.7 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; shows a 50% and 20% decrease in proliferation for AsPC-1 and CD18/HPAF cells at 25 uM; also reduces migration of pancreatic cancer cells.
| Name | Rac1-IN-1 |
|---|
| Description | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 8.3±1.7 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; shows a 50% and 20% decrease in proliferation for AsPC-1 and CD18/HPAF cells at 25 uM; also reduces migration of pancreatic cancer cells. |
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| References | References 1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600. View Related Products by Target Small GTPase |
| Molecular Formula | C19H14N2O5 |
|---|---|
| Molecular Weight | 350.33 |