701223-06-5
701223-06-5 structure
- Name: Rac1-IN-6
- Chemical Name: Rac1-IN-6
- CAS Number: 701223-06-5
- Molecular Formula: C23H20N2O2S
- Molecular Weight: 388.485
- Create Date: 2020-01-19 20:28:55
- Modify Date: 2023-01-14 16:17:07
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A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 22.4±3.2 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; inhibits the proliferation, reduces migration of pancreatic cancer cells.
| Name | Rac1-IN-6 |
|---|
| Description | A novel selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM; diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 22.4±3.2 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells; inhibits the proliferation, reduces migration of pancreatic cancer cells. |
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| References | References 1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600. View Related Products by Target Small GTPase |
| Molecular Formula | C23H20N2O2S |
|---|---|
| Molecular Weight | 388.485 |