859724-30-4
859724-30-4 structure
- Name: MRS 2481
- Chemical Name: MRS 2481
- CAS Number: 859724-30-4
- Molecular Formula: C22H30BrNO2
- Molecular Weight: 420.391
- Create Date: 2020-01-11 17:01:50
- Modify Date: 2024-02-08 14:18:00
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MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity; also is a potent inhibitor of TNFα-induced phosphorylation and proteosomal destruction of IκBα, inhibits both NFκB and AP-1 signaling on the IL-8 promoter (IC50=1.8 uM); blocks TNFα-activated phosphorylation of JNK, the c-JUN kinase.
| Name | MRS 2481 |
|---|
| Description | MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity; also is a potent inhibitor of TNFα-induced phosphorylation and proteosomal destruction of IκBα, inhibits both NFκB and AP-1 signaling on the IL-8 promoter (IC50=1.8 uM); blocks TNFα-activated phosphorylation of JNK, the c-JUN kinase. |
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| References | References 1. Diaz JC, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53. 2. Tchilibon S, et al. Biochem Pharmacol. 2005 Aug 1;70(3):381-93. View Related Products by Target Amyloids |
| Molecular Formula | C22H30BrNO2 |
|---|---|
| Molecular Weight | 420.391 |