874902-18-8
874902-18-8 structure
- Name: LY 2318912
- Chemical Name: LY 2318912
- CAS Number: 874902-18-8
- Molecular Formula: C12H12IN9O2
- Molecular Weight: 441.193
- Create Date: 2020-01-11 20:02:50
- Modify Date: 2024-01-08 20:04:24
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LY 2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd o f7.62 nM; elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents.
| Name | LY 2318912 |
|---|
| Description | LY 2318912 is a potent, competitive, small molecule inhibitor of anandamide uptake with IC50 of 7.27 nM, shows high affinity against anandamide transporter binding site with Kd o f7.62 nM; elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function in rodents. |
|---|---|
| References | References 1. Moore SA, et al. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17852-7. 2. Ortar G, et al. Eur J Med Chem. 2008 Jan;43(1):62-72. View Related Products by Target FAAH |
| Molecular Formula | C12H12IN9O2 |
|---|---|
| Molecular Weight | 441.193 |