107889-32-7
107889-32-7 structure
- Name: LY 178002
- Chemical Name: 5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
- CAS Number: 107889-32-7
- Molecular Formula: C18H25NO2S
- Molecular Weight: 319.46200
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
- Create Date: 2017-02-25 16:30:51
- Modify Date: 2024-01-30 16:49:01
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LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.
| Name | 5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one |
|---|---|
| Synonyms | LY 178002 |
| Description | LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase. |
|---|---|
| Related Catalog | |
| Target |
5-Lipoxygenase (5-LPO):0.6 μM (IC50) PLA2:6.3 μM (IC50) FCO:4.2 μM (IC50) Cyclooxygenase |
| In Vitro | LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1]. |
| In Vivo | LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1]. |
| References |
| Density | 1.139g/cm3 |
|---|---|
| Boiling Point | 489.9ºC at 760 mmHg |
| Molecular Formula | C18H25NO2S |
| Molecular Weight | 319.46200 |
| Flash Point | 250.1ºC |
| Exact Mass | 319.16100 |
| PSA | 78.12000 |
| LogP | 4.42450 |
| Vapour Pressure | 3.2E-10mmHg at 25°C |
| Index of Refraction | 1.591 |
| Storage condition | 2-8℃ |