1073549-11-7
1073549-11-7 structure
- Name: TD-0212 TFA
- Chemical Name: TD-0212 TFA
- CAS Number: 1073549-11-7
- Molecular Formula: C30H35F4N3O6S
- Molecular Weight: 641.67
- Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
- Create Date: 2020-01-23 19:04:51
- Modify Date: 2024-01-12 17:59:34
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TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
| Name | TD-0212 TFA |
|---|
| Description | TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1]. |
|---|---|
| Related Catalog | |
| Target |
pKi: 8.9 (AT1) .pIC50: 9.2 (NEP)[1]. |
| In Vitro | TD-0212 provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition[1]. |
| In Vivo | TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension[1]. |
| References |
| Molecular Formula | C30H35F4N3O6S |
|---|---|
| Molecular Weight | 641.67 |