1148125-93-2

1148125-93-2 structure

Name: DHODH-IN-4
Chemical Name: DHODH-IN-4
CAS Number: 1148125-93-2
Molecular Formula: C₁₇H₁₂Cl₂N₂O₂
Molecular Weight: 347.20
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2020-04-09 06:47:48
Modify Date: 2024-01-10 11:34:07
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].

Name	DHODH-IN-4

Description	DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC50 values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase Research Areas >> Inflammation/Immunology
Target	IC50: 4 μM (PfDHODH), 0.18 μM (HsDHODH)[1].
References	[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93.

Molecular Formula	C₁₇H₁₂Cl₂N₂O₂
Molecular Weight	347.20