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1644156-41-1

1644156-41-1 structure
1644156-41-1 structure
  • Name: DHODH-IN-9
  • Chemical Name: DHODH-IN-9
  • CAS Number: 1644156-41-1
  • Molecular Formula: C21H23FN4O
  • Molecular Weight: 366.43
  • Catalog: Signaling Pathways Anti-infection Influenza Virus
  • Create Date: 2020-04-09 15:38:14
  • Modify Date: 2024-01-17 01:11:30
  • DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].

Name DHODH-IN-9
Description DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].
Related Catalog
Target

pMIC50: 7.4 (DHODH)[1]

In Vitro DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].
References

[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

Molecular Formula C21H23FN4O
Molecular Weight 366.43
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