DHODH-IN-9

Modify Date: 2024-01-17 01:11:30

DHODH-IN-9 Structure
DHODH-IN-9 structure
Common Name DHODH-IN-9
CAS Number 1644156-41-1 Molecular Weight 366.43
Density N/A Boiling Point N/A
Molecular Formula C21H23FN4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DHODH-IN-9


DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].

 Names

Name DHODH-IN-9

 DHODH-IN-9 Biological Activity

Description DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].
Related Catalog
Target

pMIC50: 7.4 (DHODH)[1]

In Vitro DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].
References

[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

 Chemical & Physical Properties

Molecular Formula C21H23FN4O
Molecular Weight 366.43
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