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61533-47-9

61533-47-9 structure
61533-47-9 structure
  • Name: Fibrinopeptide A, human TFA
  • Chemical Name: Fibrinopeptide A, human TFA
  • CAS Number: 61533-47-9
  • Molecular Formula: C67H99F6N19O30
  • Molecular Weight: 1764.62
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2020-04-23 09:00:21
  • Modify Date: 2024-01-12 04:08:21
  • Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain[1].

Name Fibrinopeptide A, human TFA
Description Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain[1].
Related Catalog
In Vitro The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to the central region of fibrinogen and catalyzes cleavage of the 2 short peptides, the 16-residue fibrinopeptide A (FpA) and the 14-residue fibrinopeptide B (FpB), located at the NH2-termini of the Aα and Bβ chains, respectively[1].
In Vivo Fibrinopeptide A (FPA) is a small polypeptide cleaved from fibrinogen by thrombin, has a short half-life, and is considered a sensitive biochemical marker of thrombin activity, fibrin generation, and ongoing thrombosis[2].
References

[1]. Riedel T, et al. Fibrinopeptides A and B release in the process of surface fibrin formation. Blood. 2011 Feb 3;117(5):1700-6.

[2]. Manolis AS, et al. Plasma level changes of fibrinopeptide A after uncomplicated coronary angioplasty. Clin Cardiol. 1993 Jul;16(7):548-52.

Molecular Formula C67H99F6N19O30
Molecular Weight 1764.62