Fibrinopeptide A, human TFA

Modify Date: 2024-01-12 04:08:21

Fibrinopeptide A, human TFA Structure
Fibrinopeptide A, human TFA structure
Common Name Fibrinopeptide A, human TFA
CAS Number 61533-47-9 Molecular Weight 1764.62
Density N/A Boiling Point N/A
Molecular Formula C67H99F6N19O30 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fibrinopeptide A, human TFA


Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain[1].

 Names

Name Fibrinopeptide A, human TFA

 Fibrinopeptide A, human TFA Biological Activity

Description Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH2-termini of the Aα chain[1].
Related Catalog
In Vitro The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to the central region of fibrinogen and catalyzes cleavage of the 2 short peptides, the 16-residue fibrinopeptide A (FpA) and the 14-residue fibrinopeptide B (FpB), located at the NH2-termini of the Aα and Bβ chains, respectively[1].
In Vivo Fibrinopeptide A (FPA) is a small polypeptide cleaved from fibrinogen by thrombin, has a short half-life, and is considered a sensitive biochemical marker of thrombin activity, fibrin generation, and ongoing thrombosis[2].
References

[1]. Riedel T, et al. Fibrinopeptides A and B release in the process of surface fibrin formation. Blood. 2011 Feb 3;117(5):1700-6.

[2]. Manolis AS, et al. Plasma level changes of fibrinopeptide A after uncomplicated coronary angioplasty. Clin Cardiol. 1993 Jul;16(7):548-52.

 Chemical & Physical Properties

Molecular Formula C67H99F6N19O30
Molecular Weight 1764.62