1094048-77-7
1094048-77-7 structure
- Name: I-OMe-Tyrphostin AG 538
- Chemical Name: I-OMe-Tyrphostin AG 538
- CAS Number: 1094048-77-7
- Molecular Formula: C17H12INO5
- Molecular Weight: 437.19
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK IGF-1R
- Create Date: 2020-04-13 23:05:34
- Modify Date: 2024-01-12 10:17:29
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I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM[1].
| Name | I-OMe-Tyrphostin AG 538 |
|---|
| Description | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50 of 1 µM[1]. |
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| Related Catalog | |
| Target |
IC50: 1 µM (PI5P4Kα)[1] |
| In Vitro | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) (0.1-1000 µM; 24 hours) is cytotoxic to PANC-1 cells in nutrient-deprived medium[1]. I-OMe-Tyrphostin AG 538 (0-3 µM; 1 hour) blocks phosphorylation of IGF-1R, Akt and Erk[1]. Cell Viability Assay[1] Cell Line: PANC-1 cells Concentration: 0.1, 1, 10, 1000 µM Incubation Time: 24 hours Result: Cytotoxic to PANC-1 cells in nutrient-deprived medium. Western Blot Analysis[1] Cell Line: PANC-1 cells (stimulation with 50 ng/ml IGF-1 for 10 min) Concentration: 0.03, 0.3, 3 µM Incubation Time: 1 hour Result: Blocked phosphorylation of IGF-1R, Akt and Erk. |
| References |
| Molecular Formula | C17H12INO5 |
|---|---|
| Molecular Weight | 437.19 |
| Hazard Codes | Xi |
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