877950-01-1

877950-01-1 structure

Name: LtaS-IN-1
Chemical Name: LtaS-IN-1
CAS Number: 877950-01-1
Molecular Formula: C₂₄H₁₇N₃O₅
Molecular Weight: 427.41
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-04-07 16:20:58
Modify Date: 2024-01-10 10:59:09
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].

Name	LtaS-IN-1

Description	LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 0.5 μg/mL (strain E1630); 0.5 μg/mL (strain E1590)[1]
In Vitro	LtaS-IN-1 (0-100 μM) inhibits strain E745 growth as a concentration-dependent manner. At the concentration 10 μM leads to an 60% reduction in the final OD600 for this strain. Meanwhile, LtaS-IN-1 does not affect E. faecium growth in control group[1]. LtaS-IN-1 is against Enterococcus spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 inhibits strain E1630 and E1590 with the MIC values of 0.5μg/mL[1]. LtaS-IN-1 (20 μM) combines with either ampicillin (20 μg/mL), gentamicin (10 μg/mL), linezolid (5 μg/mL), daptomycin (10 μg/mL+50 μg/mL calcium chloride) or vancomycin (20 μg/mL) can inhibit strains E7128 and E7130 growth by 97-100%, while LtaS-IN-1 alone only gives 73% (strain E7128) and 8% (strain E7130) of growth inhibition, respectively[1].
References	[1]. Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents. 2017 Mar;49(3):355-363.

Molecular Formula	C₂₄H₁₇N₃O₅
Molecular Weight	427.41

Hazard Codes	Xi

877950-01-1	1964515-43-2
2573979-31-2	2123491-32-5
924296-18-4	877225-09-7
1889281-94-0	1207358-59-5
2730022-10-1	2648290-28-0
1158522-08-7	940364-43-2
134104-43-1	2580244-65-9
131615-57-1	6906-52-1
1442079-67-5	930439-75-1
1018584-77-4	1375289-11-4