2143096-93-7

2143096-93-7 structure

Name: Navitoclax-piperazine
Chemical Name: Navitoclax-piperazine
CAS Number: 2143096-93-7
Molecular Formula: C₄₇H₅₆ClF₃N₆O₅S₃
Molecular Weight: 973.63
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2020-04-09 07:57:48
Modify Date: 2025-08-26 18:38:58
Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

Name	Navitoclax-piperazine

Description	Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bcl-xL
References	[1]. Sajid Khan, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25, 1938–1947 (2019).

Molecular Formula	C₄₇H₅₆ClF₃N₆O₅S₃
Molecular Weight	973.63

Hazard Codes	Xi