Navitoclax-piperazine

Modify Date: 2024-01-02 13:48:45

Navitoclax-piperazine structure	Common Name	Navitoclax-piperazine
	CAS Number	2143096-93-7	Molecular Weight	973.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₅₆ClF₃N₆O₅S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Navitoclax-piperazine

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

Name	Navitoclax-piperazine

Description	Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Bcl-xL
References	[1]. Sajid Khan, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25, 1938–1947 (2019).

Molecular Formula	C₄₇H₅₆ClF₃N₆O₅S₃
Molecular Weight	973.63

Hazard Codes	Xi

Navitoclax-piperazine

Use of Navitoclax-piperazine

Names

Navitoclax-piperazine Biological Activity

Chemical & Physical Properties

Safety Information