1541207-06-0

1541207-06-0 structure

Name: SBFI-26
Chemical Name: SBFI-26
CAS Number: 1541207-06-0
Molecular Formula: C₂₈H₂₂O₄
Molecular Weight: 422.47
Catalog: Signaling Pathways Metabolic Enzyme/Protease FABP
Create Date: 2020-04-14 10:09:56
Modify Date: 2024-01-09 17:27:23
SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects[1][2].

Name	SBFI-26

Description	SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FABP Research Areas >> Neurological Disease
Target	Ki: 0.9 μM (FABP5), 0.4 µM (FABP7)[1][2]
In Vitro	SBFI-26 binds to the canonical ligand-binding pocket of FABP5[1]. SBFI-26 significantly inhibits cellular AEA accumulation[2].
In Vivo	SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema[2]. SBFI-26 produces antinociceptive and anti-inflammatory effects in mice[2]. Animal Model: Mice[2] Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.
References	[1]. Berger WT, et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One. 2012;7(12):e50968. [2]. Hsu HC, et al. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry. 2017 Jul 11;56(27):3454-3462.

Molecular Formula	C₂₈H₂₂O₄
Molecular Weight	422.47