SBFI-26

Modify Date: 2025-09-04 20:43:17

SBFI-26 structure	Common Name	SBFI-26
	CAS Number	1541207-06-0	Molecular Weight	422.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SBFI-26

SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects[1][2].

Name	SBFI-26

Description	SBFI-26 is a selective and competitive inhibitor of fatty acid binding proteins FABP5 and FABP7, with Kis of 0.9 µM and 0.4 µM for FABP5 and FABP7, respectively. SBFI-26 produces anti-nociceptive and anti-inflammatory effects[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> FABP Research Areas >> Neurological Disease
Target	Ki: 0.9 μM (FABP5), 0.4 µM (FABP7)[1][2]
In Vitro	SBFI-26 binds to the canonical ligand-binding pocket of FABP5[1]. SBFI-26 significantly inhibits cellular AEA accumulation[2].
In Vivo	SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema[2]. SBFI-26 produces antinociceptive and anti-inflammatory effects in mice[2]. Animal Model: Mice[2] Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.
References	[1]. Berger WT, et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One. 2012;7(12):e50968. [2]. Hsu HC, et al. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry. 2017 Jul 11;56(27):3454-3462.

Molecular Formula	C₂₈H₂₂O₄
Molecular Weight	422.47
InChIKey	NVOKBONTLOAJKA-ZCCOPBOASA-N
SMILES	O=C(O)C1C(c2ccccc2)C(C(=O)Oc2cccc3ccccc23)C1c1ccccc1

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SBFI-26

Use of SBFI-26

Names

SBFI-26 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.