2387505-50-0
2387505-50-0 structure
- Name: Cyprodime hydrochloride
- Chemical Name: Cyprodime hydrochloride
- CAS Number: 2387505-50-0
- Molecular Formula: C22H30ClNO3
- Molecular Weight: 391.93
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2020-06-01 15:14:08
- Modify Date: 2024-01-13 14:41:33
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Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2].
| Name | Cyprodime hydrochloride |
|---|
| Description | Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with Ki values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect[1][2]. |
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| Related Catalog | |
| Target |
Ki: 5.4 nM (μ-opioid), 244.6 nM (δ-opioid) and 2187 nM (κ-opioid)[1] |
| In Vitro | Cyprodime hydrochloride has Ki values of 8.1 nM and 26.6 nM for μ-opioid receptor in rat brain (Wistar) and guinea pig brain[1]. |
| In Vivo | Cyprodime hydrochloride (3, 10 mg/kg; i.p.; 60 min prior to test) significantly increases immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg. Cyprodime hydrochloride increases the grooming time[2]. Animal Model: Male NMRI mice aged 21-25 days and weighing 10-12 g[2] Dosage: 3, 10 mg/kg Administration: IP; 60 min prior to test Result: Significantly increased immobility time in the forced swimming test (FST) with higher dose of 10 mg/kg. |
| References |
| Molecular Formula | C22H30ClNO3 |
|---|---|
| Molecular Weight | 391.93 |