1404060-15-6
1404060-15-6 structure
- Name: D-Cl-amidine
- Chemical Name: D-Cl-amidine
- CAS Number: 1404060-15-6
- Molecular Formula: C14H19ClN4O2
- Molecular Weight: 310.78
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-06-01 10:48:23
- Modify Date: 2025-08-25 15:12:43
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D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].
| Name | D-Cl-amidine |
|---|
| Description | D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1]. |
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| Related Catalog | |
| In Vitro | D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1]. |
| In Vivo | D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1]. |
| References |
| Molecular Formula | C14H19ClN4O2 |
|---|---|
| Molecular Weight | 310.78 |