D-Cl-amidine

Modify Date: 2025-08-25 15:12:43

D-Cl-amidine structure	Common Name	D-Cl-amidine
	CAS Number	1404060-15-6	Molecular Weight	310.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₉ClN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of D-Cl-amidine

D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].

Name	D-Cl-amidine

Description	D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
In Vitro	D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1]. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1].
In Vivo	D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].
References	[1]. Bicker KL, et al. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.

Molecular Formula	C₁₄H₁₉ClN₄O₂
Molecular Weight	310.78

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: D-Cl-amidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

D-Cl-amidine suppliers

D-Cl-amidine price