Name | ESI-08 |
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Description | ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1]. |
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Related Catalog | |
Target |
IC50: 8.4 μM (EPAC2)[1] EPAC1[1] |
In Vitro | Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |
References |
Molecular Formula | C20H23N3OS |
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Molecular Weight | 353.48 |
Storage condition | -20°C |