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  • DC Chemicals Limited
  • China
  • Product Name: ESI-08
  • Price: ¥700.0/100mg ¥1200.0/250mg ¥2400.0/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

301177-43-5

301177-43-5 structure
301177-43-5 structure
  • Name: ESI-08
  • Chemical Name: ESI-08
  • CAS Number: 301177-43-5
  • Molecular Formula: C20H23N3OS
  • Molecular Weight: 353.48
  • Catalog: Signaling Pathways GPCR/G Protein Ras
  • Create Date: 2020-06-01 14:47:24
  • Modify Date: 2024-01-10 18:46:05
  • ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].

Name ESI-08
Description ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
Related Catalog
Target

IC50: 8.4 μM (EPAC2)[1] EPAC1[1]

In Vitro Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].
References

[1]. Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

Molecular Formula C20H23N3OS
Molecular Weight 353.48
Storage condition -20°C