ESI-08
Modify Date: 2024-01-10 18:46:05
ESI-08 structure
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Common Name | ESI-08 | ||
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| CAS Number | 301177-43-5 | Molecular Weight | 353.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ESI-08ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1]. |
| Name | ESI-08 |
|---|
| Description | ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1]. |
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| Related Catalog | |
| Target |
IC50: 8.4 μM (EPAC2)[1] EPAC1[1] |
| In Vitro | Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. |
| References |
| Molecular Formula | C20H23N3OS |
|---|---|
| Molecular Weight | 353.48 |
| Storage condition | -20°C |