ESI-08

Modify Date: 2024-01-10 18:46:05

ESI-08 Structure
ESI-08 structure
Common Name ESI-08
CAS Number 301177-43-5 Molecular Weight 353.48
Density N/A Boiling Point N/A
Molecular Formula C20H23N3OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ESI-08


ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].

 Names

Name ESI-08

 ESI-08 Biological Activity

Description ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
Related Catalog
Target

IC50: 8.4 μM (EPAC2)[1] EPAC1[1]

In Vitro Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1].
References

[1]. Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

 Chemical & Physical Properties

Molecular Formula C20H23N3OS
Molecular Weight 353.48
Storage condition -20°C
Top Suppliers:I want be here



Get all suppliers and price by the below link:

ESI-08 suppliers

ESI-08 price