1001382-14-4

1001382-14-4 structure

Name: Ipatasertib-NH2
Chemical Name: Ipatasertib-NH2
CAS Number: 1001382-14-4
Molecular Formula: C₂₁H₂₆ClN₅O₂
Molecular Weight: 415.92
Create Date: 2020-06-01 20:41:33
Modify Date: 2024-02-01 18:17:23
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1].

Name	Ipatasertib-NH2

Description	Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1].
Related Catalog	Research Areas >> Cancer
Target	AKT[1]
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.