394237-61-7
394237-61-7 structure
- Name: M77976
- Chemical Name: M77976
- CAS Number: 394237-61-7
- Molecular Formula: C17H16N2O3
- Molecular Weight: 296.32
- Catalog: Signaling Pathways Metabolic Enzyme/Protease PDHK
- Create Date: 2020-06-01 18:04:49
- Modify Date: 2024-01-20 13:31:17
-
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].
| Name | M77976 |
|---|
| Description | M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 648 μM (PDK4)[1] |
| In Vitro | M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid[1]. M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4[1]. |
| References |
| Molecular Formula | C17H16N2O3 |
|---|---|
| Molecular Weight | 296.32 |