M77976

Modify Date: 2026-07-03 21:44:39

M77976 structure	Common Name	M77976
	CAS Number	394237-61-7	Molecular Weight	296.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of M77976

M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].

Name	M77976

Description	M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PDHK Research Areas >> Metabolic Disease
Target	IC50: 648 μM (PDK4)[1]
In Vitro	M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid[1]. M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4[1].
References	[1]. Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):763-73.

Molecular Formula	C₁₇H₁₆N₂O₃
Molecular Weight	296.32
InChIKey	GSBFARPNIZUMHA-UHFFFAOYSA-N
SMILES	COc1ccc(-c2c(-c3ccc(O)cc3O)n[nH]c2C)cc1

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ...
Source: NCGC
External Id: huntington-HTTAS8-p1-FF-overN

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr

Name: Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS2-PP-HEK293ACE2-f4-mipe-npc

Name: VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-VSVG-PP-HEK293ACE2-f4-mipe-npc

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: M77976
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Purity: 99.0%
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Contact: Yang
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.