Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK-0493
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: Mk-0493
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

455956-93-1

455956-93-1 structure

455956-93-1 structure

Name: Mk-0493
Chemical Name: MK-0493
CAS Number: 455956-93-1
Molecular Formula: C₃₀H₃₈ClF₂N₃O₂
Molecular Weight: 546.09
Catalog: Research Areas Endocrinology
Create Date: 2020-06-01 12:17:00
Modify Date: 2024-01-13 12:03:15
MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

Name	MK-0493

Description	MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].
Related Catalog	Research Areas >> Endocrinology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
In Vivo	MK-0493 dose-dependently increases electrically evoked increases in ICP[2]. MK-0493 is shown to promote robust weight loss activity following oral administration in preclinical animal models, suggesting the drug can access the target site in the hypothalamus[3].
References	[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [2]. Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21(2):311-5. [3]. Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4.

Molecular Formula	C₃₀H₃₈ClF₂N₃O₂
Molecular Weight	546.09