Mk-0493

Modify Date: 2024-01-13 12:03:15

Mk-0493 structure	Common Name	Mk-0493
	CAS Number	455956-93-1	Molecular Weight	546.09
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₈ClF₂N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mk-0493

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

Name	MK-0493

Description	MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].
Related Catalog	Research Areas >> Endocrinology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
In Vivo	MK-0493 dose-dependently increases electrically evoked increases in ICP[2]. MK-0493 is shown to promote robust weight loss activity following oral administration in preclinical animal models, suggesting the drug can access the target site in the hypothalamus[3].
References	[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [2]. Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21(2):311-5. [3]. Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4.

Molecular Formula	C₃₀H₃₈ClF₂N₃O₂
Molecular Weight	546.09

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK-0493
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Mk-0493
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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